Nephrotic Syndrome Prognosis and Life Expectancy

Conventional treatment for Nephrotic Syndrome is steroids and immunosuppressants, but they have a lot of side effects, and the disease gets relapse frequently. If you would like to try alternatives and get permanent treatment of the disease, systemic Chinese medicine will be a good choice for you. After a short period of treatment, edema will disappear completely, and proteinuria will turn negative.

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These Types of Nephrotic Syndrome Are More likely to Progress to Uremia

2019-01-25 15:43

These Types of Nephrotic Syndrome Are More likely to Progress to UremiaToday, we divide Nephrotic Syndrome into two categories: Nephrotic Syndrome that is easy to treat and has good prognosis; and Nephrotic Syndrome that is difficult to treat and has bad prognosis.

1. Nephrotic Syndrome that is easy to treat.

Feature: Primary Nephrotic Syndrome + heavy swelling

Pathology type: Mostly minimal change disease, membranous nephropathy, etc.

This type of Nephrotic Syndrome is usually sensitive to steroids and immunosuppressants. After medication for several weeks or two or three months, urinary protein can be reduced to about 0.5g, and renal failure and uremia are rare to happen.

Also, because of the obvious edema, these patients are able to see the symptoms in early stage so as to seize the best opportunities for treatment, which is one of the reasons it is easy to treat. Before kidney failure, the obvious symptoms are only edema and gross hematuria. Generally patients with obvious symptoms receive treatment more timely.

This seemingly fierce Nephrotic Syndrome usually has a better prognosis than that without edema.

2. Refractory Nephrotic Syndrome

(1) Primary Nephrotic Syndrome

Feature: In most case, there is no heavy edema.

Pathological types: focal segmental glomerulosclerosis (FSGS), partial IgA Nephropathy, membranous proliferative nephritis, membranous nephropathy stage 3 and 4, etc.

Due to the poor pathology of these Nephrotic Syndrome, there is often no significant improvement in urinary protein after the use of steroids and immunosuppressive agents, which leads to rapid progress and a greater risk of renal failure.

Because of the lack of edema, a large number of these patients do not know they have kidney disease in the early and middle stage, and have not been treated. Many patients only find kidney disease when their kidney failure is severe, or even when they progress to uremia.

(2) Secondary Nephrotic Syndrome

-Diabetic Nephropathy

Diabetic Nephropathy is one of the most difficult kidney disease to treat, and is divided into five stages. Once manifested as Nephrotic Syndrome, the patients’ disease has progressed to stage 4, which is more difficult to treat and more easy to progress into uremia.

-Lupus Nephritis

This is the most dangerous form of kidney disease.

If lupus nephritis is manifested as nephrotic syndrome and a large amount of proteinuria, it is mostly in the active stage of lupus nephritis type 4 or 5 and severe type 3, and the disease is in critical condition. Steroids and immunosuppressive agents should be used as soon as possible to prevent rapid progression to uremia, and even hemodialysis should be used to control the disease and protect life safety.

-Purpura Nephritis

Pathological types: most of them are mesangial proliferative glomerulonephritis and crescent nephritis

If the manifestation of purpura nephritis is nephrotic syndrome, the pathological type is poor, the risk of developing into uremia is higher, and timely Immunotherapy is needed, otherwise the risk of developing into uremia is high.

-Hereditary or congenital nephrotic syndrome

Alport syndrome (hereditary nephritis) is an inherited glomerular basement membrane disease. Currently, no drugs can improve the damage of type 4 collagen in the tissue basement membrane of Alport syndrome. The use of cyclosporine and ACEI drugs can properly delay the progression, and patients often develop to uremia in the young and middle-aged period.

Fabry's disease, also known as diffuse cutaneous keratinoma, is an inherited disease. Kidney damage may occur with age. Currently, enzyme replacement therapy is widely used (which is expensive), and renal failure is the most common and serious complication.

Congenital nephrotic syndrome: nephrotic syndrome occurs within three months of birth, and even in utero. Steroids and immunosuppressive therapy often fail to work, and the only treatment is kidney transplantation.

With congenital nephrotic syndrome, it is usually difficult to lower proteinuria, and the prognosis is bad, which can be only treated with diuretics, anti-hypertensive drugs and some other symptomatic treatment.


Although nephrotic syndrome has two categories: easy to treat and difficult to treat, there are individual differences. We may also find: with the same kidney disease, the same pathology, and the same treatment, two patients have different therapeutic effects.

The progress of nephrotic syndrome should be judged not only by the disease itself, but also by the patient's compliance, living habits, economic ability, drug response and so on.

Therefore, even if you have nephrotic syndrome that is difficult to treat, as long as you have correct diagnosis, treatment and recuperation, you can get an ideal therapeutic effect.

As for you own illness conditions, you can get some guidance related to diet, exercise, medicines or some natural remedies. The online consultation service is free. Please remember to leave your email address, or phone number so that we can contact you and help you!
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This is a girl from Saudi Arabic. After about half a month of treatment in our hospital, her leg edema disappeared, and the effect was very obvious.

Nephrotic Syndrome Patient from New Zealand Paid Second Visit to Our Hospital